Am J Psychiatry 1995; 152:1807-1809
Copyright © 1995 by American Psychiatric Association
Elevation of CSF somatostatin concentrations in mania
RP Sharma, G Bissette, PG Janicak, JM Davis and CB Nemeroff
Department of Psychiatry, University of Illinois at Chicago, USA.
OBJECTIVE: The aim of this study was to compare levels of CSF somatostatin
(somatotropin release-inhibiting factor) in drug-free patients with
different major psychiatric disorders. METHOD: CSF somatostatin
concentrations were measured in 66 drug-free inpatients with Research
Diagnostic Criteria diagnoses of schizophrenia, major depressive disorder,
manic disorder, or schizoaffective disorder. RESULTS: In comparison with
both the patients with schizophrenia and the patients with schizoaffective
disorder, the manic patients had markedly elevated CSF somatostatin
concentrations. The depressed patients had significantly higher levels than
the schizophrenic patients. CONCLUSIONS: Mania is associated with
relatively higher CSF somatostatin concentrations.
