Am J Psychiatry 1995; 152:1801-1803
Copyright © 1995 by American Psychiatric Association
Abnormalities of regional distribution of cerebral vasculature in schizophrenia detected by dynamic susceptibility contrast MRI
BM Cohen, D Yurgelun-Todd, CD English and PF Renshaw
Brain Imaging Center, McLean Hospital, Belmont, MA 02178, USA.
OBJECTIVE: The authors tested the hypothesis that the regional distribution
of cerebral vasculature is anomalous in schizophrenia. METHOD: Dynamic
susceptibility contrast magnetic resonance imaging was used to evaluate
cerebral blood volume in the right and left occipital cortex, basal
ganglia, and cerebellum of 10 subjects with schizophrenia and 10 healthy
comparison subjects. RESULTS: Cerebral blood volume was greater in the
schizophrenic subjects in every region studied. CONCLUSIONS: The findings
suggest an abnormality of the configuration of cerebral blood vessels in
schizophrenia.
