|
| | |
|
Am J Psychiatry 1995; 152:1757-1764
Copyright © 1995 by American Psychiatric Association
Predictors of cognitive change in middle-aged and older adults with memory loss
GW Small, A La Rue, S Komo, A Kaplan and MA Mandelkern
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, School of Medicine, USA.
OBJECTIVE: Previous longitudinal studies of age-related memory loss have
focused on objective neuropsychological measures that predict subsequent
cognitive change, yet brain metabolic function, self- perception of memory
loss, and other measures may also be sensitive indicators of cognitive
change. To determine such baseline predictors of change, the authors made
longitudinal assessments of middle-aged and older adults with memory loss.
METHOD: Forty-two persons (mean age = 60 years, range = 43-81) with memory
complaints received comprehensive baseline assessments, including
subjective neuropsychological measures, objective measures of
visual-spatial memory (the Benton Visual Retention Test) and verbal memory
(the Buschke-Fuld Selective Reminding Test), and positron emission
tomography scans to determine neocortical glucose metabolism. At an average
follow-up of 3 years, the objective neuropsychological measures were again
used to quantify the degree of cognitive change. RESULTS: Multiple
regression analyses indicated that parietal asymmetry, sex of the subject,
and baseline visual-spatial memory score were significant predictors of
change in visual-spatial memory; level of education and baseline verbal
memory score predicted change in verbal memory. Other neocortical asymmetry
scores, age, family history of Alzheimer's disease, cerebral atrophy, and
self- ratings of use of mnemonics were not significant predictors of
change. CONCLUSIONS: Measures of cerebral metabolism, objective memory
performance, sex, and education may predict subsequent cognitive change in
middle-aged and older persons with memory loss. Also, the parietal
asymmetry found in persons with questionable dementia that progresses to
probable Alzheimer's disease may be present very early in the course of
age-related cognitive decline.
This article has been cited by other articles:
|
|
|
|
 
D. Blacker, H. Lee, A. Muzikansky, E. C. Martin, R. Tanzi, J. J. McArdle, M. Moss, and M. Albert
Neuropsychological Measures in Normal Individuals That Predict Subsequent Cognitive Decline
Arch Neurol,
June 1, 2007;
64(6):
862 - 871.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.A. Luis, D.A. Loewenstein, A. Acevedo, W.W. Barker, and R. Duara
Mild cognitive impairment: Directions for future research
Neurology,
August 26, 2003;
61(4):
438 - 444.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Yoshitani, M. Kawaguchi, N. Sugiyama, M. Sugiyama, S. Inoue, T. Sakamoto, K. Kitaguchi, and H. Furuya
The Association of High Jugular Bulb Venous Oxygen Saturation with Cognitive Decline After Hypothermic Cardiopulmonary Bypass
Anesth. Analg.,
June 1, 2001;
92(6):
1370 - 1376.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Morris, M. Storandt, J. P. Miller, D. W. McKeel, J. L. Price, E. H. Rubin, and L. Berg
Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease
Arch Neurol,
March 1, 2001;
58(3):
397 - 405.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. H.S. Silverman and M. E. Phelps
Evaluating Dementia Using PET: How Do We Put into Clinical Perspective What We Know to Date?
J. Nucl. Med.,
November 1, 2000;
41(11):
1929 - 1932.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Aleman, H. J. J. Verhaar, E. H. F. de Haan, W. R. de Vries, M. M. Samson, M. L. Drent, E. A. van der Veen, and H. P. F. Koppeschaar
Insulin-Like Growth Factor-I and Cognitive Function in Healthy Older Men
J. Clin. Endocrinol. Metab.,
February 1, 1999;
84(2):
471 - 475.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Can We Predict Cognitive Change in Adults with Memory Loss?
Journal Watch Psychiatry,
February 1, 1996;
1996(201):
8 - 8.
[Full Text]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1995
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
