|
| | |
|
Am J Psychiatry 1995; 152:31-36
Copyright © 1995 by American Psychiatric Association
Atypical depression: clinical aspects and noradrenergic function
GM Asnis, LK McGinn and WC Sanderson
Department of Psychiatry, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10467.
OBJECTIVE: The authors assessed the frequency of atypical depression in
depressed outpatients and compared clinical and biological features of
patients with atypical and nonatypical depression. METHOD: Depressed
outpatients (N = 114) were diagnosed with the Schedule for Affective
Disorders and Schizophrenia (SADS) according to Research Diagnostic
Criteria. Patients were assessed for presence or absence of atypical
depression with the Atypical Depressive Disorder Scale. Atypical depression
was defined as the presence of mood reactivity during the depressive
episode, along with at least one of four associated features: hypersomnia,
hyperphagia, leaden paralysis, and rejection sensitivity. All patients
completed the SCL-90 and were rated with the Hamilton Depression Rating
Scale, extracted from the SADS. To assess biological functioning, the
authors examined cortisol response to 75 mg of desipramine, a relatively
selective norepinephrine reuptake inhibitor. RESULTS: Twenty-nine percent
of patients met criteria for atypical depression. Patients with atypical
depression were significantly more likely to be female. Patients with
atypical and nonatypical depression did not differ on SCL-90 subscale
scores. Although extracted Hamilton depression scale scores were
significantly higher for patients with nonatypical depression, the
difference was not clinically significant. Patients with atypical
depression exhibited a significantly different cortisol response to
desipramine injection than patients with nonatypical depression, which
suggested that nonatypical depression may be associated with a more
impaired norepinephrine system. CONCLUSIONS: In view of data in this study,
as well as earlier studies, atypical depression has a unique symptom
profile, may be widely prevalent, has a distinct treatment response, and
may indicate a less impaired biological system than nonatypical depression.
Since this is the first report to evaluate the frequency of atypical
depression as well as the norepinephrine system in atypical depression,
this study needs to be replicated. Nonetheless, the data support the
inclusion of atypical depression as a subtype of the depressive disorders
in DSM-IV.
This article has been cited by other articles:
|
|
|
|
 
S. Paradiso, J. Vaidya, D. Tranel, T. Kosier, and R. G. Robinson
Nondysphoric Depression Following Stroke
J Neuropsychiatry Clin Neurosci,
February 1, 2008;
20(1):
52 - 61.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. S. Matza, D. A. Revicki, J. R. Davidson, and J. W. Stewart
Depression With Atypical Features in the National Comorbidity Survey: Classification, Description, and Consequences
Arch Gen Psychiatry,
August 1, 2003;
60(8):
817 - 826.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Casacalenda, J. C. Perry, and K. Looper
Remission in Major Depressive Disorder: A Comparison of Pharmacotherapy, Psychotherapy, and Control Conditions
Am J Psychiatry,
August 1, 2002;
159(8):
1354 - 1360.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Posternak and M. Zimmerman
Partial Validation of the Atypical Features Subtype of Major Depressive Disorder
Arch Gen Psychiatry,
January 1, 2002;
59(1):
70 - 76.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Levitan, R. B. Jarrett, M. Schaffer, D. McIntire, A. Witt-Browder, D. Kraft, and R. C. Risser
Treatment of Atypical Depression With Cognitive Therapy or Phenelzine
Arch Gen Psychiatry,
November 1, 2000;
57(11):
1084 - 1084.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Benazzi
Late-Life Atypical Major Depressive Episode: A 358-Case Study In Outpatients
Am J Geriatr Psychiatry,
May 1, 2000;
8(2):
117 - 122.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. J. McGrath, J. W. Stewart, M. N. Janal, E. Petkova, F. M. Quitkin, and D. F. Klein
A Placebo-Controlled Study of Fluoxetine Versus Imipramine in the Acute Treatment of Atypical Depression
Am J Psychiatry,
March 1, 2000;
157(3):
344 - 350.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. D. Levitan, S. V. Parikh, A. D. Lesage, K. M. Hegadoren, M. Adams, S. H. Kennedy, and P. N. Goering
Major Depression in Individuals With a History of Childhood Physical or Sexual Abuse: Relationship to Neurovegetative Features, Mania, and Gender
Am J Psychiatry,
December 1, 1998;
155(12):
1746 - 1752.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. F. Sullivan, R. C. Kessler, and K. S. Kendler
Latent Class Analysis of Lifetime Depressive Symptoms in the National Comorbidity Survey
Am J Psychiatry,
October 1, 1998;
155(10):
1398 - 1406.
[Abstract]
[Full Text]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1995
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
