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Am J Psychiatry 1994; 151:1372-1374
Copyright © 1994 by American Psychiatric Association
Lithium and tricyclic augmentation of fluoxetine treatment for resistant major depression: a double-blind, controlled study
M Fava, JF Rosenbaum, PJ McGrath, JW Stewart, JD Amsterdam and FM Quitkin
Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114.
Forty-one patients who had failed to respond to 8 weeks of treatment with
20 mg of fluoxetine were randomly assigned to one of three treatments for 4
weeks: 40-60 mg/day of fluoxetine, 20 mg/day of fluoxetine plus 25-50
mg/day of desipramine, and 20 mg/day of fluoxetine plus 300-600 mg/day of
lithium. Patients treated with high- dose fluoxetine (N = 15) did
significantly better than patients treated with fluoxetine plus lithium (N
= 14) and those treated with fluoxetine plus desipramine (N = 12).
High-dose fluoxetine was the most effective treatment among partial
responders to previous treatment, but high-dose fluoxetine and fluoxetine
plus lithium were the most effective treatments among nonresponders.
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