Am J Psychiatry 1994; 151:1369-1371
Copyright © 1994 by American Psychiatric Association
Platelet serotonin measures in primary dysthymia
AV Ravindran, J Chudzik, RJ Bialik, YD Lapierre and PD Hrdina
Department of Psychiatry, University of Ottawa, Ont., Canada.
Serotonergic function in 22 patients with primary dysthymia and 22 normal
volunteers was evaluated by measuring [3H]serotonin uptake and
[3H]paroxetine binding in platelets. A significantly lower maximum rate of
serotonin uptake was noted in the dysthymic patients than in the normal
subjects, indicating a possible serotonergic dysfunction in dysthymia.
However, the values for parameters of paroxetine binding were similar in
the two groups.
