Am J Psychiatry 1994; 151:752-755
Copyright © 1994 by American Psychiatric Association
Basal ganglia pathology in schizophrenia and tardive dyskinesia: an MRI quantitative study
AM Elkashef, RW Buchanan, F Gellad, RC Munson and A Breier
NIMH Neuroscience Center, St. Elizabeths Hospital, Washington, D.C. 20032.
Magnetic resonance imaging was used to measure the volumes of the caudate,
putamen, and globus pallidus of 25 schizophrenic patients (17 men and eight
women) and 26 age- and sex-matched comparison subjects (18 men and eight
women). Schizophrenic patients had significantly larger right and left
globus pallidus and right putamen volumes than comparison subjects. There
were no significant differences between schizophrenic patients with and
without persistent tardive dyskinesia in the volume of any of the three
structures.
