Lack of association between cortisol hypersecretion and nonsuppression on the DST in patients with Alzheimer's disease



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	Articles by Miller, A. H.
	Articles by Davis, K. L.

Am J Psychiatry 1994; 151:267-270
Copyright © 1994 by American Psychiatric Association

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Lack of association between cortisol hypersecretion and nonsuppression on the DST in patients with Alzheimer's disease

AH Miller, G Sastry, AJ Speranza Jr, BA Lawlor, RC Mohs, TM Ryan, SM Gabriel, M Serby, J Schmeidler and KL Davis
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029.

Among 23 patients with Alzheimer's disease, 11 (48%) exhibited cortisol hypersecretion (> or = 11.8 micrograms/dl) and nine (39%) displayed cortisol nonsuppression on the dexamethasone suppression test. Only four patients exhibited both neuroendocrine abnormalities, demonstrating a lack of association between these two neuroendocrine disturbances of over 50%. Twenty-two of the 23 patients were studied for 4 1/2 years, and 14 died during that period. Six of the eight surviving patients exhibited cortisol hypersecretion without cortisol nonsuppression.

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