|
| | |
|
Am J Psychiatry 1994; 151:1735-1739
Copyright © 1994 by American Psychiatric Association
Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia
SP Roose, AH Glassman, E Attia and S Woodring
New York State Psychiatric Institute, NY 10032.
OBJECTIVE: The popularity of selective serotonin reuptake inhibitors stems
from their apparent efficacy for numerous disorders and their favorable
side effect profile. However, several studies have suggested that selective
serotonin reuptake inhibitors may be relatively ineffective for treating
melancholia. The objective of this study was to compare the responses to
fluoxetine and nortriptyline of older patients with both severe depression
and heart disease. METHOD: The outcome of 22 hospitalized patients with
unipolar depression and heart disease who were treated with fluoxetine was
compared to the outcome of 42 comparable patients treated with
nortriptyline. The average age of the fluoxetine group was 73 years, and
their mean pretreatment score on the Hamilton Depression Rating Scale was
26; the average age of the nortriptyline group was 70, and their mean
pretreatment Hamilton score was 28. RESULTS: Of the 42
nortriptyline-treated patients, 28 were responders, six were nonresponders,
and eight dropped out. The intent- to-treat response rate was 67% (28 of
42), and the response rate of the melancholic patients who completed the
nortriptyline trial was 83% (20 of 24). Of the 22 fluoxetine-treated
patients, five were responders, 13 were nonresponders, and four dropped
out. The intent-to-treat response rate was 23% (five of 22), and the
response rate of the melancholic patients who completed the fluoxetine
trial was 10% (one of 10). CONCLUSIONS: Fluoxetine appears to be
significantly less effective than nortriptyline for treating hospitalized
elderly patients with unipolar major affective disorder, especially those
with the melancholic subtype and concurrent cardiovascular disease.
This article has been cited by other articles:
|
|
|
|
 
A. Schatzberg and S. Roose
A Double-Blind, Placebo-Controlled Study of Venlafaxine and Fluoxetine in Geriatric Outpatients With Major Depression
Am J Geriatr Psychiatry,
April 1, 2006;
14(4):
361 - 370.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. E. Lotrich and B. G. Pollock
Aging and Clinical Pharmacology: Implications for Antidepressants
J. Clin. Pharmacol.,
October 1, 2005;
45(10):
1106 - 1122.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. I. Papakostas, T. Petersen, J. Pava, E. Masson, J. J. Worthington III, J. E. Alpert, M. Fava, and A. A. Nierenberg
Hopelessness and Suicidal Ideation in Outpatients With Treatment-Resistant Depression: Prevalence and Impact on Treatment Outcome
Focus,
January 1, 2005;
3(1):
140 - 145.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. Hildebrandt, E. W. Steyerberg, K. B. Stage, J. Passchier, P. Kragh-Soerensen, and The Danish University Antidepressant Group
Are Gender Differences Important for the Clinical Effects of Antidepressants?
Am J Psychiatry,
September 1, 2003;
160(9):
1643 - 1650.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Dwight-Johnson, I. T. Lagomasino, and G. M. Simpson
Psychopharmacology: Underuse of Evidence-Based Pharmacotherapies for Affective Disorders
Psychiatr Serv,
August 1, 2003;
54(8):
1076 - 1078.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. H. Mulsant, B. G. Pollock, R. Nebes, M. D. Miller, R. A. Sweet, J. Stack, P. R. Houck, S. Bensasi, S. Mazumdar, and C. F. Reynolds III
A Twelve-Week, Double-Blind, Randomized Comparison of Nortriptyline and Paroxetine in Older Depressed Inpatients and Outpatients
Am J Geriatr Psychiatry,
November 1, 2001;
9(4):
406 - 414.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Shelton and A. J. Tomarken
Can Recovery From Depression Be Achieved?
Psychiatr Serv,
November 1, 2001;
52(11):
1469 - 1478.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. PARKER
New' and old' antidepressants: all equal in the eyes of the lore?
The British Journal of Psychiatry,
August 1, 2001;
179(2):
95 - 96.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. A. Sackeim, R. F. Haskett, B. H. Mulsant, M. E. Thase, J. J. Mann, H. M. Pettinati, R. M. Greenberg, R. R. Crowe, T. B. Cooper, and J. Prudic
Continuation Pharmacotherapy in the Prevention of Relapse Following Electroconvulsive Therapy: A Randomized Controlled Trial
JAMA,
March 14, 2001;
285(10):
1299 - 1307.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Weintraub
Nortriptyline in Geriatric Depression Resistant to Serotonin Reuptake Inhibitors: Case Series
J Geriatr Psychiatry Neurol,
March 1, 2001;
14(1):
28 - 32.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. J. M. H. Strik, A. Honig, R. Lousberg, A. H. P. Lousberg, E. C. Cheriex, H. G. Tuynman-Qua, P. M. J. C. Kuijpers, H. J. J. Wellens, and H. M. Van Praag
Efficacy and Safety of Fluoxetine in the Treatment of Patients With Major Depression After First Myocardial Infarction: Findings From a Double-Blind, Placebo-Controlled Trial
Psychosom Med,
December 1, 2000;
62(6):
783 - 789.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. L. Stern, N. A. Votolato, J. P. Hatch, and C. L. Bowden
The Newer Antidepressants
Psychiatr Serv,
August 1, 2000;
51(8):
1051 - 1052.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Fraser
Antidepressant choice to minimise treatment resistance
The British Journal of Psychiatry,
May 1, 2000;
176(5):
493 - 493.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R C Baldwin, P. Haddad, R H McAllister-Williams, C. Gordon, M. G Livingston, and H. M Livingston
Antidepressants for old people
BMJ,
September 25, 1999;
319(7213):
849b - 849.
[Full Text]
|
|
|
|
|
|
|
T. A. Slotkin, D. B. Miller, F. Fumagalli, E. C. McCook, J. Zhang, G. Bissette, and F. J. Seidler
Modeling Geriatric Depression in Animals: Biochemical and Behavioral Effects of Olfactory Bulbectomy in Young Versus Aged Rats
J. Pharmacol. Exp. Ther.,
April 1, 1999;
289(1):
334 - 345.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D. L. Musselman, D. L. Evans, and C. B. Nemeroff
The Relationship of Depression to Cardiovascular Disease: Epidemiology, Biology, and Treatment
Arch Gen Psychiatry,
July 1, 1998;
55(7):
580 - 592.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. P. Roose, A. H. Glassman, E. Attia, S. Woodring, E.-G. V. Giardina, and J. T. Bigger Jr.
Cardiovascular Effects of Fluoxetine in Depressed Patients With Heart Disease
Am J Psychiatry,
May 1, 1998;
155(5):
660 - 665.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C.B. Kelly and S.J. Cooper
Differences and variability in plasma noradrenaline between depressive and anxiety disorders
J Psychopharmacol,
January 1, 1998;
12(2):
161 - 167.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. M. Lane
SSRI-Induced extrapyramidal side-effects and akathisia: implications for treatment
J Psychopharmacol,
January 1, 1998;
12(2):
192 - 214.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B. J. Goldstein and P. J Goodnick
Selective serotonin reuptake inhibitors in the treatment of affective disorders--III. Tolerability, safety and pharmacoeconomics
J Psychopharmacol,
January 1, 1998;
12(4_suppl):
55 - S87.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. J. Goodnick and B. J. Goldstein
Selective serotonin reuptake inhibitors in affective disorders -II. Efficacy and quality of life
J Psychopharmacol,
January 1, 1998;
12(4_suppl):
S21 - S54.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. D. Amsterdam
Selective serotonin reuptake inhibitor efficacy in severe and melancholic depression
J Psychopharmacol,
January 1, 1998;
12(4_suppl):
S99 - S111.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. J. Knesper
The Depressions of Alzheimer's Disease: Sorting, Pharmacotherapy, and Clinical Advice
J Geriatr Psychiatry Neurol,
October 1, 1995;
8(1):
S40 - S51.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Bernadt and R. Hammill
Study's conclusion is unwarranted
BMJ,
July 1, 1995;
311(6996):
56 - 56.
[Full Text]
|
|
|
|
|
|
|
SSRIs vs. TCAs: The Controversy Continues
Journal Watch Psychiatry,
February 1, 1995;
1995(201):
2 - 2.
[Full Text]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1994
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
