Am J Psychiatry 1994; 151:1701-1703
Copyright © 1994 by American Psychiatric Association

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Central serotonergic hyperresponsivity in late-onset Alzheimer's disease

DM McLoughlin, JV Lucey and TG Dinan
Department of Psychiatry, Trinity College Medical School, St. James's Hospital, London, England.

The prolactin response to oral d-fenfluramine (30 mg) was measured in nine patients with late-onset Alzheimer's disease and in an elderly comparison group. The serotonin-mediated prolactin response was significantly greater in the patients with Alzheimer's disease than in the comparison group. This finding suggests that central serotonin responsivity is greater in Alzheimer's disease.

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