Effects of low-dose TRH on cognitive deficits in the ECT postictal state



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Am J Psychiatry 1994; 151:1694-1696
Copyright © 1994 by American Psychiatric Association

BRIEF REPORTS

Effects of low-dose TRH on cognitive deficits in the ECT postictal state

A Khan, MH Mirolo, K Claypoole, J Bhang, G Cox, A Horita and G Tucker
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195.

A low dose (0.5 mg) of thyrotropin-releasing hormone (TRH), a short- acting tripeptide with known analeptic properties, was administered to eight depressed patients 5 minutes after ECT session 3 or 4 in a double- blind, placebo-controlled crossover design. After TRH infusion the patients displayed selectively better performance on a battery of neuropsychological tests than they did after placebo infusion. Further exploration with pharmacological probes to mitigate ECT postictal cognitive deficits is warranted.

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