The American Journal of Psychiatry
Journal Home Search Current Issue Past Issues Subscribe All APPI Journals Help Contact Us
 
Quicksearch
Advanced Search
Or Search All APPI Journals
This Article
* Full Text (PDF)
* Alert me when this article is cited
* Alert me if a correction is posted
* Citation Map
Services
* Email this article to a Colleague
* Similar articles in this journal
* Similar articles in PubMed
* Alert me to new issues of the journal
* Add to My Articles & Searches
* Download to citation manager
* reprints & permissions
Citing Articles
* Citing Articles via HighWire
* Citing Articles via Google Scholar
Google Scholar
* Articles by Lawlor, B. A.
* Articles by Davis, K. L.
* Search for Related Content
PubMed
* PubMed Citation
* Articles by Lawlor, B. A.
* Articles by Davis, K. L.

Am J Psychiatry 1994; 151:1646-1649
Copyright © 1994 by American Psychiatric Association


REGULAR ARTICLES

Clinical symptoms associated with age at onset in Alzheimer's disease

BA Lawlor, TM Ryan, J Schmeidler, RC Mohs and KL Davis
Department of Psychiatry, Mount Sinai Medical Center, New York.

OBJECTIVE: The aim of the study was to examine the relationship between age at onset of Alzheimer's disease and demographic and clinical characteristics in a large cohort of patients with Alzheimer's disease. METHOD: The subjects were 104 patients meeting the criteria for Alzheimer's disease of the National Institute of Neurological and Communicative Disorders and Stroke. The relationships of age at disease onset to cognitive and noncognitive variables and to rate of progression were explored by using multiple regression analysis. RESULTS: Earlier disease onset was associated with the presence of greater language and praxis difficulties and with the development of higher depression scores during the follow-up study period but not with faster disease progression. CONCLUSIONS: These findings suggest that in Alzheimer's disease, which is a clinically heterogeneous illness, younger age at onset may be related to the presence of more prominent language and praxis impairment and to development of greater depression during the disease course.


This article has been cited by other articles:


Home page
J. Neurol. Neurosurg. PsychiatryHome page
L Mosconi, K Herholz, I Prohovnik, B Nacmias, M T R De Cristofaro, M Fayyaz, L Bracco, S Sorbi, and A Pupi
Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve
J. Neurol. Neurosurg. Psychiatry, January 1, 2005; 76(1): 15 - 23.
[Abstract] [Full Text] [PDF]


Home page
AM J ALZHEIMERS DIS OTHER DEMENHome page
J. C. A. Lasprilla, J. Iglesias, and F. Lopera
Neuropsychological stydy of familial Alzheimer's disease caused by mutation E280A in the presenilin 1 gene
American Journal of Alzheimer's Disease and Other Dementias, May 1, 2003; 18(3): 137 - 146.
[Abstract] [PDF]


Home page
NeurologyHome page
N. Hirono, M. Hashimoto, M. Yasuda, K. Ishii, S. Sakamoto, H. Kazui, and E. Mori
The effect of APOE {epsilon}4 allele on cerebral glucose metabolism in AD is a function of age at onset
Neurology, March 12, 2002; 58(5): 743 - 750.
[Abstract] [Full Text] [PDF]


Home page
Arch NeurolHome page
C. H. van Dyck, J. Gelernter, M. G. MacAvoy, R. A. Avery, M. Criden, O. Okereke, P. Varma, J. P. Seibyl, and P. B. Hoffer
Absence of an Apolipoprotein E {epsilon}4 Allele Is Associated With Increased Parietal Regional Cerebral Blood Flow Asymmetry in Alzheimer Disease
Arch Neurol, November 1, 1998; 55(11): 1460 - 1466.
[Abstract] [Full Text] [PDF]


Home page
Arch NeurolHome page
W. Reid, G. Broe, H. Creasey, D. Grayson, E. McCusker, H. Bennett, W. Longley, and M. R. Sulway
Age at Onset and Pattern of Neuropsychological Impairment in Mild Early-Stage Alzheimer Disease: A Study of a Community-Based Population
Arch Neurol, October 1, 1996; 53(10): 1056 - 1061.
[Abstract] [PDF]




Get information about faster international access.

Privacy Policy

Copyright © 1994 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us

American Psychiatric Publishing, Inc. American Psychiatric Association
1000 Wilson Boulevard, Suite 1825, Arlington, VA 22209-3901 * 800-368-5777 * appi at psych.org