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Am J Psychiatry 1994; 151:1631-1636
Copyright © 1994 by American Psychiatric Association
The effect of depression treatment on elderly patients' preferences for life-sustaining medical therapy
L Ganzini, MA Lee, RT Heintz, JD Bloom and DS Fenn
Psychiatry Service, Portland VA Medical Center, OR 97207.
OBJECTIVE: This study was undertaken 1) to test the hypothesis that
remission of depression results in an increase in desire for life-
sustaining medical therapy and 2) to characterize patients whose desire for
life-sustaining treatment increases substantially following depression
therapy. METHOD: Elderly patients, suffering from major depression, were
interviewed on admission to a psychiatric inpatient unit and at discharge
about their desire for specific medical therapies in their current state of
health and in two hypothetical scenarios of medical illness. A psychiatrist
rated the impact of depressive thinking on the subject's response to these
questions. Forty-three subjects completed the study, and 24 were in
remission from depression at the time of discharge. RESULTS: In the
majority of patients, remission of depression did not result in an increase
in desire for life-sustaining medical therapy. However, a clinically
evident increase in desire for life-sustaining medical therapies followed
treatment of depression in subjects (N = 11 [26%]) who had been initially
rated as more severely depressed, more hopeless, and more likely to
overestimate the risks and to underestimate the benefits of treatment.
CONCLUSIONS: In major depression of mild to moderate severity, a patient's
desire to forgo life-sustaining medical treatment is unlikely to be altered
by depression treatment. On the other hand, severely depressed patients,
particularly those who are hopeless, overestimate the risks of treatment,
or underestimate the benefits of treatment, should be encouraged to defer
advance treatment directives. In these patients decisions about
life-sustaining therapy should be discouraged until after treatment of the
depression.
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