Greater hemodynamic response to photic stimulation in schizophrenic patients: an echo planar MRI study



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Am J Psychiatry 1994; 151:1493-1495
Copyright © 1994 by American Psychiatric Association

REGULAR ARTICLES

Greater hemodynamic response to photic stimulation in schizophrenic patients: an echo planar MRI study

PF Renshaw, DA Yurgelun-Todd and BM Cohen
McLean Brain Imaging Center, Belmont, MA 02178.

Functional echo planar magnetic resonance imaging (MRI) probably will be of importance in assessing brain abnormalities in psychiatric disorders. The authors used functional MRI to measure the relative magnitude of the change in image signal intensity, reflecting changes in regional neuronal activity caused by photic stimulation, in eight patients with schizophrenia and nine normal comparison subjects. The mean signal intensity change in the primary visual cortex was significantly greater in patients with schizophrenia (mean = 4.6%, SD = 1.5%) than in normal comparison subjects (mean = 3.1%, SD = 1.3%). These results may reflect a variety of factors, including diffuse structural brain changes as well as primary or iatrogenic impairment of mitochondrial function or energy metabolism.

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