Am J Psychiatry 1993; 150:1415-1416
Copyright © 1993 by American Psychiatric Association
Prediction of response to haloperidol dose reduction by Span of Apprehension measures for treatment-refractory schizophrenic patients
MF Green, J Mintz, L Bowen, BD Marshall Jr, TG Kuehnel, JL Hayden and RP Liberman
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine.
Thirteen treatment-refractory schizophrenic patients participated in a
haloperidol reduction study. Two of the subjects were unable to tolerate
medication reduction. These subjects were comparable to the other patients
in terms of initial clinical variables but were outliers on baseline
accuracy and reaction time measures from the Span of Apprehension. The
results suggest that aspects of basic visual processing and motor response
speed may identify patients who require higher neuroleptic doses.
