Am J Psychiatry 1993; 150:1408-1410
Copyright © 1993 by American Psychiatric Association
Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients
J Licinio, JP Seibyl, M Altemus, DS Charney and JH Krystal
Department of Psychiatry, Yale University School of Medicine, West Haven Veterans Affairs Medical Center, CT 06516.
Levels of CSF fluid interleukin-2, but not interleukin-1 alpha, were found
to be higher in 10 neuroleptic-free schizophrenic patients than in 10
healthy subjects matched for sex and age. Because interleukin-2 increases
dopaminergic neurotransmission and participates in autoimmunity and cell
growth, the authors postulate that elevated levels of central interleukin-2
might contribute to the increased dopaminergic neurotransmission,
autoimmune phenomena, and abnormal brain morphology described in some
patients with schizophrenia.
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