Am J Psychiatry 1993; 150:1252-1254
Copyright © 1993 by American Psychiatric Association
Elevated platelet membrane phosphatidylinositol-4,5-bisphosphate in bipolar mania
AS Brown, AG Mallinger and LC Renbaum
Department of Psychiatry, University of Pittsburgh School of Medicine, Pa.
Membrane phospholipids were measured in platelets of seven medication- free
patients in the manic phase of bipolar affective disorder and seven healthy
comparison subjects. The relative percentage of platelet membrane
phosphatidylinositol-4,5-bisphosphate was significantly higher in the manic
patients than in the comparison subjects. These results are consistent with
an enhanced neuronal second messenger response after 5-hydroxytryptamine
receptor stimulation followed by neurotransmitter release.
