Elevated growth hormone responses to pyridostigmine in obsessive- compulsive disorder: evidence of cholinergic supersensitivity



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Am J Psychiatry 1993; 150:961-962
Copyright © 1993 by American Psychiatric Association

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Elevated growth hormone responses to pyridostigmine in obsessive- compulsive disorder: evidence of cholinergic supersensitivity

JV Lucey, G Butcher, AW Clare and TG Dinan
Department of Psychiatry, Trinity College Medical School, St. James Hospital, Dublin, Ireland.

The growth hormone response to the acetylcholinesterase inhibitor pyridostigmine was measured in nine normothymic outpatients who met DSM- III-R criteria for obsessive-compulsive disorder. The responses were significantly elevated when compared to those found in a healthy comparison group (N = 9). The data suggest that cholinergic supersensitivity is present in obsessive-compulsive disorder.

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