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Am J Psychiatry 1993; 150:891-895
Copyright © 1993 by American Psychiatric Association
Evidence for the independent familial transmission of attention deficit hyperactivity disorder and learning disabilities: results from a family genetic study
SV Faraone, J Biederman, BK Lehman, K Keenan, D Norman, LJ Seidman, R Kolodny, I Kraus, J Perrin and WJ Chen
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114.
OBJECTIVE: The purpose of the study was to clarify the relationship between
attention deficit hyperactivity disorder and learning disabilities. METHOD:
The authors assessed learning disabilities in a sample of 140 children with
attention deficit hyperactivity disorder and in 120 normal comparison
children. They also assessed a sample of the probands' 822 first-degree
relatives. RESULTS: The risk for learning disabilities was highest among
relatives of probands with both attention deficit hyperactivity disorder
and learning disabilities. The two disorders did not cosegregate in
families. There was nonrandom mating between spouses with attention deficit
hyperactivity disorder and learning disabilities. CONCLUSIONS: The two
disorders are transmitted independently in families, and their
co-occurrence may be due to nonrandom mating. Attention deficit
hyperactivity disorder is likely to be etiologically independent from
learning disabilities.
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