Am J Psychiatry 1993; 150:813-815
Copyright © 1993 by American Psychiatric Association
CSF transthyretin in patients with depression
JA Hatterer, J Herbert, C Hidaka, SP Roose and JM Gorman
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
Some depressed patients may suffer from restricted central hypothyroidism,
which could occur if levels of the thyroid hormone transport protein
transthyretin were low. CSF transthyretin was measured in eight inpatients
with refractory major depression and nine neurological patients. The
depressed patients had significantly lower transthyretin levels than the
comparison subjects, suggesting that central hypothyroidism, with normal
peripheral thyroid concentrations, could occur in some depressed patients.
