Adrenal androgens and cortisol in major depression



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Am J Psychiatry 1993; 150:806-809
Copyright © 1993 by American Psychiatric Association

REGULAR ARTICLES

Adrenal androgens and cortisol in major depression

H Osran, C Reist, CC Chen, ET Lifrak, A Chicz-DeMet and LN Parker
Department of Psychiatry, Long Beach VA Medical Center, CA 90822.

Nine depressed subjects and nine comparison subjects completed a study of abnormalities in adrenal androgen and cortisol metabolism. Serum levels of cortisol and dehydroepiandrosterone (DHA) at 8:00 a.m. and 4:00 p.m. revealed hypercortisolemia and loss of diurnal DHA variation but not cortisol variation in the depressed group. These findings suggest that in depression, adrenal androgens, in contrast to cortisol, are partially regulated by mechanisms independent of ACTH.

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