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Am J Psychiatry 1993; 150:713-719
Copyright © 1993 by American Psychiatric Association
Neural correlates of self-induced dysphoria
JV Pardo, PJ Pardo and ME Raichle
Department of Psychiatry, Washington University Medical Center, St. Louis.
OBJECTIVE: The authors explored the question of whether acute, transient
changes in mood are reflected in activation of discrete neuronal systems in
the human brain. METHOD: Using positron emission tomography, they measured
the regional cerebral blood flow (CBF) of seven psychiatrically healthy
subjects under two conditions. During the control condition the subjects
were resting with their eyes closed. During the active condition, with
their eyes still closed, they were asked to imagine or recall a situation
that would make them feel very sad. They were explicitly asked to
experience sadness and to avoid any feelings of anger or anxiety. RESULTS:
There were significant differences in regional CBF measured during the
control condition and during the active condition, particularly in the
inferior and orbitofrontal cortices. Women showed bilateral inferior and
orbitofrontal activation, but men displayed predominantly left-sided
activation in these areas. CONCLUSIONS: The authors conclude that the
inferior and orbitofrontal cortices play an important role in normal
emotional cognitive processes.
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