Am J Psychiatry 1993; 150:656-657
Copyright © 1993 by American Psychiatric Association
Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression
MD De Bellis, PW Gold, TD Geracioti Jr, SJ Listwak and MA Kling
Clinical Neuroendocrinology Branch, NIMH, Bethesda, MD 20892.
The authors measured CSF concentrations of corticotropin-releasing hormone
(CRH) and arginine vasopressin in nine depressed patients before and after
fluoxetine treatment. They found significant decreases in CSF CRH, CSF
arginine vasopressin, and Hamilton depression ratings. Thus, the
therapeutic effect of this serotonin-uptake inhibitor may be related to
diminution of these arousal-promoting neuropeptides.
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