Am J Psychiatry 1993; 150:647-649
Copyright © 1993 by American Psychiatric Association

BRIEF REPORTS

Limited therapeutic effect of addition of buspirone in fluvoxamine- refractory obsessive-compulsive disorder

CJ McDougle, WK Goodman, JF Leckman, JC Holzer, LC Barr, E McCance-Katz, GR Heninger and LH Price
Clinical Neuroscience Research Unit, Yale University School of Medicine, Connecticut Mental Health Center, New Haven 06519.

The authors found that buspirone added to the treatment of 33 patients with obsessive-compulsive disorder who were refractory to the serotonin reuptake inhibitor fluvoxamine was no better than placebo in reducing obsessive-compulsive, depressive, or anxiety symptoms. This finding suggests that addition of buspirone to ongoing fluvoxamine therapy is not an effective treatment strategy for most patients with obsessive- compulsive disorder.

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