Am J Psychiatry 1993; 150:508-510
Copyright © 1993 by American Psychiatric Association
Subclinical hypothyroidism: a modifiable risk factor for depression?
JJ Haggerty Jr, RA Stern, GA Mason, J Beckwith, CE Morey and AJ Prange Jr
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill.
The authors assessed the lifetime history of major depression in 16
subjects with subclinical hypothyroidism and 15 subjects whose thyroid
function was completely normal. The lifetime frequency of depression was
significantly higher in the subjects who met the criteria for subclinical
hypothyroidism (56%) than in those who did not (20%), suggesting that
subclinical hypothyroidism may lower the threshold for the occurrence of
depression.
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