Am J Psychiatry 1993; 150:505-507
Copyright © 1993 by American Psychiatric Association
The effect of zidovudine on neuropsychiatric measures in HIV-infected men
JM Gorman, R Mayeux, Y Stern, JB Williams, J Rabkin, RR Goetz and AA Ehrhardt
HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, NY 10032.
The authors examined the effects of zidovudine on neuropsychiatric
measures, at three assessment points separated by 6 months, in 25 HIV-
positive men who took zidovudine for at least 6 months and a comparison
group of 25 HIV-positive men with similar CD4+ T cell counts who had never
taken zidovudine. Zidovudine had no statistically significant effect except
for a slight improvement in Global Assessment of Functioning scale score.
In this small group of subjects there was little benefit but also little
evidence of CNS toxicity from zidovudine.
