|
| | |
|
Am J Psychiatry 1993; 150:286-293
Copyright © 1993 by American Psychiatric Association
Pathological laughing and crying following stroke: validation of a measurement scale and a double-blind treatment study
RG Robinson, RM Parikh, JR Lipsey, SE Starkstein and TR Price
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.
OBJECTIVE: This study was undertaken to test the reliability and validity
of the Pathological Laughter and Crying Scale and the effectiveness of
nortriptyline treatment for patients with emotional lability following
stroke. METHOD: Eighty-two patients with ischemic brain injury-54 who had
been hospitalized with acute stroke and 28 others who requested treatment
for pathological laughing and crying-- were given standardized psychiatric
and neurological assessments and then administered the Pathological
Laughter and Crying Scale. The 54 acute stroke patients were used to
evaluate the Pathological Laughter and Crying Scale, and the 28 patients
with pathological emotional display were randomly assigned to nortriptyline
treatment or placebo in a 6-week double-blind trial to assess the efficacy
of a tricyclic antidepressant in treatment of this disorder. RESULTS: The
interrater reliability on the Pathological Laughter and Crying Scale for a
subgroup of 15 patients was 0.93, and the test-retest reliability of the
scale was excellent. After 4 and 6 weeks of treatment, scores on the
Pathological Laughter and Crying Scale showed significantly greater
improvement in the 14 patients given nortriptyline than in the 14 given
placebo. Although almost one-half of these patients also had major
depression, the improvement in emotional lability was independent of
depression status. In addition, response to treatment was not significantly
affected by lesion location or time since stroke. CONCLUSIONS: The severity
of symptoms in pathological emotional display can be reliably quantified
with the Pathological Laughter and Crying Scale, and treatment with
nortriptyline can effectively ameliorate this emotional disorder.
This article has been cited by other articles:
|
|
|
|
 
E. Townend, M. Brady, and K. McLaughlan
A Systematic Evaluation of the Adaptation of Depression Diagnostic Methods for Stroke Survivors Who Have Aphasia
Stroke,
November 1, 2007;
38(11):
3076 - 3083.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Parvizi and R. Schiffer
Exaggerated Crying and Tremor With a Cerebellar Cyst
J Neuropsychiatry Clin Neurosci,
May 1, 2007;
19(2):
187 - 190.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H Kosaka, N Omata, M Omori, T Shimoyama, T Murata, K Kashikura, T Takahashi, J Murayama, Y Yonekura, and Y Wada
Abnormal pontine activation in pathological laughing as shown by functional magnetic resonance imaging.
J. Neurol. Neurosurg. Psychiatry,
December 1, 2006;
77(12):
1376 - 1380.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Schiffer and L. E. Pope
Review of Pseudobulbar Affect Including a Novel and Potential Therapy
J Neuropsychiatry Clin Neurosci,
November 1, 2005;
17(4):
447 - 454.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Bates, J. Y. Choi, P. W. Duncan, J. J. Glasberg, G. D. Graham, R. C. Katz, K. Lamberty, D. Reker, and R. Zorowitz
Veterans Affairs/Department of Defense Clinical Practice Guideline for the Management of Adult Stroke Rehabilitation Care: Executive Summary
Stroke,
September 1, 2005;
36(9):
2049 - 2056.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. W. Duncan, R. Zorowitz, B. Bates, J. Y. Choi, J. J. Glasberg, G. D. Graham, R. C. Katz, K. Lamberty, and D. Reker
Management of Adult Stroke Rehabilitation Care: A Clinical Practice Guideline
Stroke,
September 1, 2005;
36(9):
e100 - e143.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A Smith, J. E Berg, L. E Pope, J. D Callahan, D. Wynn, and R. A Thisted
Validation of the CNS emotional lability scale for pseudobulbar affect (pathological laughing and crying) in multiple sclerosis patients
Multiple Sclerosis,
December 1, 2004;
10(6):
679 - 685.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A Chio, A Gauthier, A Montuschi, A Calvo, N Di Vito, P Ghiglione, and R Mutani
A cross sectional study on determinants of quality of life in ALS
J. Neurol. Neurosurg. Psychiatry,
November 1, 2004;
75(11):
1597 - 1601.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Tateno, R. E. Jorge, and R. G. Robinson
Pathological Laughing and Crying Following Traumatic Brain Injury
J Neuropsychiatry Clin Neurosci,
November 1, 2004;
16(4):
426 - 434.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Horrocks, M. L. Hackett, C. S. Anderson, and A. O. House
Pharmaceutical Interventions for Emotionalism After Stroke
Stroke,
November 1, 2004;
35(11):
2610 - 2611.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. R. Brooks, R. A. Thisted, S. H. Appel, W. G. Bradley, R. K. Olney, J. E. Berg, L. E. Pope, R. A. Smith, and for the AVP-923 ALS Study Group
Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: A randomized trial
Neurology,
October 26, 2004;
63(8):
1364 - 1370.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Wild, F. A. Rodden, W. Grodd, and W. Ruch
Neural correlates of laughter and humour
Brain,
October 1, 2003;
126(10):
2121 - 2138.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kimura, A. Tateno, and R. G. Robinson
Treatment of Poststroke Generalized Anxiety Disorder Comorbid With Poststroke Depression: Merged Analysis of Nortriptyline Trials
Am J Geriatr Psychiatry,
June 1, 2003;
11(3):
320 - 327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Huffman and T. A. Stern
Acute Psychiatric Manifestations of Stroke: A Clinical Case Conference
Psychosomatics,
February 1, 2003;
44(1):
65 - 75.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Turner-Stokes and N. Hassan
Depression after stroke: a review of the evidence base to inform the development of an integrated care pathway. Part 2: Treatment alternatives
Clinical Rehabilitation,
March 1, 2002;
16(3):
248 - 260.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. Turner-Stokes, N. Hassan, K. Pierce, and F. Clegg
Managing depression in brain injury rehabilitation: the use of an integrated care pathway and preliminary report of response to sertraline
Clinical Rehabilitation,
March 1, 2002;
16(3):
261 - 268.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Parvizi, S. W. Anderson, C. O. Martin, H. Damasio, and A. R. Damasio
Pathological laughter and crying: A link to the cerebellum
Brain,
September 1, 2001;
124(9):
1708 - 1719.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Max, B. A. M. Robertson, and A. E. Lansing
The Phenomenology of Personality Change Due to Traumatic Brain Injury in Children and Adolescents
J Neuropsychiatry Clin Neurosci,
May 1, 2001;
13(2):
161 - 170.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. House, C. Anderson, M. Hackett, R. G. Robinson, M. Kimura, and T. Kosier
Authors Should Be Accurate When Describing Study Design Response
Stroke,
April 1, 2001;
32(4):
1048 - 1049.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. ASSAL, N. VALENZA, T. LANDIS, and J.-P. HORNUNG
Clinicoanatomical correlates of a Fou rire prodromique in a pontine infarction
J. Neurol. Neurosurg. Psychiatry,
November 1, 2000;
69(5):
697 - 698.
[Full Text]
|
|
|
|
|
|
|
R. G. Robinson
An 82-Year-Old Woman With Mood Changes Following a Stroke
JAMA,
March 22, 2000;
283(12):
1607 - 1614.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. G. Robinson, S. K. Schultz, C. Castillo, T. Kopel, J. T. Kosier, R. M. Newman, K. Curdue, G. Petracca, and S. E. Starkstein
Nortriptyline Versus Fluoxetine in the Treatment of Depression and in Short-Term Recovery After Stroke: A Placebo-Controlled, Double-Blind Study
Am J Psychiatry,
March 1, 2000;
157(3):
351 - 359.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
E. Chemerinski and R. G. Robinson
The Neuropsychiatry of Stroke
Psychosomatics,
February 1, 2000;
41(1):
5 - 14.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. McCullagh and A. Feinstein
Treatment of Pathological Affect: Variability of Response for Laughter and Crying
J Neuropsychiatry Clin Neurosci,
February 1, 2000;
12(1):
100 - 102.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. F. Mendez, T. V. Nakawatase, and C. V. Brown
Involuntary Laughter and Inappropriate Hilarity
J Neuropsychiatry Clin Neurosci,
May 1, 1999;
11(2):
253 - 258.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A Feinstein, P O'Connor, T Gray, and K Feinstein
Pathological laughing and crying in multiple sclerosis: a preliminary report suggesting a role for the prefrontal cortex
Multiple Sclerosis,
April 1, 1999;
5(2):
69 - 73.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Rice-Oxley and L. Turner-Stokes
Effectiveness of brain injury rehabilitation
Clinical Rehabilitation,
January 1, 1999;
13(1_suppl):
7 - 24.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. R Moore, L. S Gresham, M. B Bromberg, E. J Kasarkis, and R. A Smith
A self report measure of affective lability
J. Neurol. Neurosurg. Psychiatry,
July 1, 1997;
63(1):
89 - 93.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1993
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
