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Am J Psychiatry 1993; 150:1849-1855
Copyright © 1993 by American Psychiatric Association
Neuropsychological correlates of MRI temporal lobe abnormalities in schizophrenia
PG Nestor, ME Shenton, RW McCarley, J Haimson, RS Smith, B O'Donnell, M Kimble, R Kikinis and FA Jolesz
Harvard Medical School, Boston, MA.
OBJECTIVE: The authors evaluated the neuropsychological correlates of
temporal lobe abnormalities in schizophrenic patients. METHOD: Fifteen
schizophrenic patients underwent assessment of memory, by the Wechsler
Memory Scale--Revised, and abstraction/categorization, by the similarities
subtest of the Wechsler Adult Intelligence Scale--Revised and the Wisconsin
Card Sorting Test. Neuropsychological tests of motor and constructional
functions were used as control tasks. The patients also underwent magnetic
resonance imaging (MRI) studies in which new neuroimaging techniques were
used to derive measurements of volume and three-dimensional surface
renderings of temporal lobe structures. RESULTS: Spearman rank-order
correlations indicated significant associations between poor scores on
tests of verbal memory, abstraction, and categorization and reduced volume
in temporal lobe structures, including the parahippocampal gyrus and
posterior superior temporal gyrus (left and right). By contrast,
performance on tests of visual memory and on control tasks was not
correlated with MRI temporal lobe abnormalities. CONCLUSIONS: These
findings suggest a significant but modest relation between reduced volume
in specific temporal lobe regions and neuropsychological deficits in
abstraction, categorization, and verbal memory, all of which may reflect a
dysfunctional semantic system in schizophrenia.
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