Am J Psychiatry 1993; 150:149-151
Copyright © 1993 by American Psychiatric Association

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CSF homovanillic acid in schizotypal personality disorder

LJ Siever, F Amin, EF Coccaro, R Trestman, J Silverman, TB Horvath, TR Mahon, P Knott, L Altstiel and M Davidson
Psychiatry Service, VA Medical Center, Bronx, NY 10468.

CSF concentrations of homovanillic acid (HVA) were measured in 10 patients with schizotypal personality disorder and 14 patients with other personality disorders. The patients with schizotypal personality disorder had higher CSF HVA concentrations than the patients with other personality disorders. Furthermore, the psychotic-like schizotypal symptoms correlated positively with the CSF HVA concentrations. These results suggest a central dopaminergic dysfunction associated with the psychotic-like symptoms of schizotypal personality disorder.

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