Replication of action of cholecystokinin tetrapeptide in panic disorder: clinical and behavioral findings



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Am J Psychiatry 1992; 149:962-964
Copyright © 1992 by American Psychiatric Association

REGULAR ARTICLES

Replication of action of cholecystokinin tetrapeptide in panic disorder: clinical and behavioral findings

J Bradwejn, D Koszycki, R Payeur, M Bourin and H Borthwick
Division of Psychopharmacology, St. Mary's Hospital Center, Montreal, PQ, Canada.

Eleven patients with panic disorder were challenged with cholecystokinin tetrapeptide (CCK-4) on two occasions. The effects of CCK-4 were consistent except symptom onset was more rapid with the second injection. Demonstrating that the effects of CCK-4 are reproducible in panic patients opens the doors for studies of the effects of drug treatment on CCK-4-induced panic.

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