Am J Psychiatry 1992; 149:958-961
Copyright © 1992 by American Psychiatric Association
Regulation of appetite and cholecystokinin secretion in anorexia nervosa
TD Geracioti Jr, RA Liddle, M Altemus, MA Demitrack and PW Gold
Clinical Neuroendocrinology Branch, NIMH, Bethesda, Md.
Six patients with anorexia nervosa, the same patients after weight
normalization, and six healthy control subjects had similar fasting and
postprandial plasma cholecystokinin concentrations. These data do not
support the hypothesis that low levels of hunger and food intake in
anorexic patients reflect hypersecretion of this endogenous hormone, which
is thought to inhibit hunger, promote satiety, and reduce feeding.