Am J Psychiatry 1992; 149:691-693
Copyright © 1992 by American Psychiatric Association
CSF cholecystokinin concentrations in patients with panic disorder and in normal comparison subjects
RB Lydiard, JC Ballenger, MT Laraia, MD Fossey and MC Beinfeld
Institute of Psychiatry, Medical University of South Carolina, Charleston 29425.
Cholecystokinin concentrations in the CSF of 25 patients with panic
disorder and 16 normal comparison subjects were ascertained by
radioimmunoassay. The patients with panic disorder had significantly lower
CSF concentrations of cholecystokinin, which may reflect increased CNS
cholecystokinin receptor sensitivity, reduced numbers of receptors, or a
compensatory reduction in cholecystokinin octapeptide secondary to
theoretically increased central cholecystokinin tetrapeptide activity.
