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Am J Psychiatry 1992; 149:641-646
Copyright © 1992 by American Psychiatric Association
Oculomotor performance in obsessive-compulsive disorder
AY Tien, GD Pearlson, SR Machlin, FW Bylsma and R Hoehn-Saric
Department of Mental Hygiene, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205.
OBJECTIVE: Neuroimaging studies have shown abnormalities of the frontal
cortex and basal ganglia in persons with obsessive-compulsive disorder.
Since lesions in the frontal cortex and basal ganglia areas affect
performance on goal-guided saccadic eye movements, this study investigated
the relation between the diagnosis of obsessive-compulsive disorder and
oculomotor performance. METHOD: Eleven patients with the clinical diagnosis
of obsessive-compulsive disorder and 14 normal subjects were assessed with
respect to their performance on both visual- guided and goal-guided
oculomotor tasks. Fixation performance was also measured. RESULTS: The
group with obsessive-compulsive disorder had a very significantly greater
error rate and a significantly greater rate of inaccurate saccades on the
goal-guided antisaccade task, whereas they were not different from the
normal group in reaction time, saccadic velocity, and accuracy on the
visual-guided saccade task. The distribution of error rates for the
patients with obsessive-compulsive disorder was broad, with more than
one-half outside the range of the normal group. Most of the abnormal
findings were among male patients. CONCLUSIONS: The results support the
hypothesis of a relationship between impaired performance on goal-guided
saccadic eye movement tasks and the diagnosis of obsessive-compulsive
disorder, but they also suggest a gender-related subgroup within the group
with obsessive- compulsive disorder.
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