Frontal, temporal, and striatal proton relaxation times in schizophrenic patients and normal comparison subjects



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Am J Psychiatry 1992; 149:549-551
Copyright © 1992 by American Psychiatric Association

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Frontal, temporal, and striatal proton relaxation times in schizophrenic patients and normal comparison subjects

P Williamson, D Pelz, H Merskey, S Morrison, S Karlik, D Drost, T Carr and P Conlon
Department of Psychiatry, University of Western Ontario, London, Canada.

Spin-lattice (T1) and spin-spin (T2) magnetic resonance relaxation times were examined in frontal, temporal, and striatal regions of 24 patients with schizophrenia and 10 normal comparison subjects. The schizophrenic patients had more prolonged T2 values than did the comparison subjects, particularly in the left temporal cortex and white matter, suggesting tissue pathology.

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