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Am J Psychiatry 1992; 149:488-493
Copyright © 1992 by American Psychiatric Association
Sensory gating deficits in schizophrenia: new results
LL Judd, L McAdams, B Budnick and DL Braff
Department of Psychiatry, University of California, San Diego.
OBJECTIVE: It has been widely hypothesized that sensory gating failures and
sensory overload occur in schizophrenic patients compared to normal
subjects. The authors of this study sought to confirm and extend results of
earlier studies that showed specific sensory gating deficits in
schizophrenic patients. METHOD: Age- and sex-matched schizophrenic patients
(N = 20) and normal subjects (N = 20) were tested using
electrophysiologically recorded P50 event-related potentials to assess the
overall competence of the subjects' central sensory inhibitory capacity by
measuring sensory filtering or gating. P50 area responses to two 75-dB
(conditioning and test) click stimuli of 0.04-msec duration, averaged over
60 trials, were recorded for each subject. Normally, the first
(conditioning) click stimulus induces gating mechanisms that result in
diminished or gated P50 event-related potentials in response to the second
click stimulus. RESULTS: The schizophrenic subjects manifested a
significant sensory gating deficit at frontal, central, and parietal
electrode placement sites, with a nonsignificant tendency for the deficit
to be most prominent in the frontal areas of the brain. CONCLUSIONS: These
data reflect a regionally diffuse loss of normal sensory gating in
schizophrenic patients.
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