|
| | |
|
Am J Psychiatry 1992; 149:341-345
Copyright © 1992 by American Psychiatric Association
Mania compared with unipolar depression in old age
KI Shulman, M Tohen, A Satlin, G Mallya and D Kalunian
McLean Hospital, Belmont, Mass.
OBJECTIVE: The goal of this study was to clarify the meaning and importance
of mania in old age. METHOD: The authors conducted a retrospective study of
50 elderly patients consecutively admitted to a private mental hospital
with an index episode of mania. As a comparison group, they used 50 age-
and sex-matched patients with unipolar depression. They reviewed the charts
of the 100 patients for family history, clinical course, and neurological
disorders. Outcome was determined by contacting patients, families,
physicians, institutional settings, and vital statistics records. Survival
analysis compared mortality rates. RESULTS: The manic patients had a
greater familial predisposition to affective disorder and were younger at
first psychiatric hospitalization. For the 20 manic patients whose first
affective episode was depression, an average of 15 years elapsed before
mania became manifest. Eighteen of the manic patients, compared with only
four of the depressed patients, had neurological disorders. The manic
patients had a significantly higher mortality rate than the depressed
patients; by the end of the follow-up, 25 of the manic patients, compared
with 10 of the depressed patients, had died. CONCLUSIONS: Mania appears to
have a poorer prognosis and to be a more severe form of affective illness
than unipolar depression. The 18 manic patients with neurological disorders
seemed to have "secondary mania." Subtle cerebral changes due to aging may
have been responsible for the conversion to mania in the 20 patients who
experienced a long latency from first depression to onset of mania. The low
frequency of early- onset mania in this study group highlights the need to
differentiate early- from late-onset mania.
This article has been cited by other articles:
|
|
|
|
 
A. G. Gildengers, E. M. Whyte, R. A. Drayer, I. Soreca, A. Fagiolini, A. M. Kilbourne, P. R. Houck, C. F. Reynolds III, E. Frank, D. J. Kupfer, et al.
Medical Burden in Late-Life Bipolar and Major Depressive Disorders
Am J Geriatr Psychiatry,
March 1, 2008;
16(3):
194 - 200.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. K. P. Woo, S. Golshan, E. C. Allen, J. W. Daly, D. V. Jeste, and D. D. Sewell
Factors associated with frequent admissions to an acute geriatric psychiatric inpatient unit.
J Geriatr Psychiatry Neurol,
December 1, 2006;
19(4):
226 - 230.
[Abstract]
[PDF]
|
|
|
|
|
|
|
F. Benazzi
Late-Life Atypical Major Depressive Episode: A 358-Case Study In Outpatients
Am J Geriatr Psychiatry,
May 1, 2000;
8(2):
117 - 122.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. J. Bartels, B. Forester, K. M. Miles, and T. Joyce
Mental Health Service Use by Elderly Patients With Bipolar Disorder and Unipolar Major Depression
Am J Geriatr Psychiatry,
May 1, 2000;
8(2):
160 - 166.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. W. Van Gerpen, J. E. Johnson, and D. K. Winstead
Mania in the Geriatric Patient Population: A Review of the Literature
Am J Geriatr Psychiatry,
August 1, 1999;
7(3):
188 - 202.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. E. Wylie, B. H. Mulsant, B. G. Pollock, R. A. Sweet, G. S. Zubenko, A. E. Begley, M. Gregor, E. Frank, C. F. Reynolds III, and D. J. Kupfer
Age at Onset in Geriatric Bipolar Disorder: Effects on Clinical Presentation and Treatment Outcomes in an Inpatient Sample
Am J Geriatr Psychiatry,
February 1, 1999;
7(1):
77 - 83.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. Fujikawa, S. Yamawaki, and Y. Touhouda
Silent Cerebral Infarctions in Patients With Late-Onset Mania
Stroke,
June 1, 1995;
26(6):
946 - 949.
[Abstract]
[Full Text]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1992
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
