Am J Psychiatry 1992; 149:199-201
Copyright © 1992 by American Psychiatric Association
Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder
MM Nothen, J Erdmann, J Korner, M Lanczik, J Fritze, R Fimmers, DK Grandy, B O'Dowd and P Propping
Department of Psychiatry, University of Bonn, Germany.
Fifty-six patients with bipolar affective disorder and 69 healthy control
subjects were tested for association of restriction fragment length
polymorphism alleles at the dopamine D1 and D2 receptor loci. No
significant associations were found; thus, the hypothesis that a single
mutant form of either receptor gene is responsible for the phenotype of
patients with bipolar affective disorder was not supported.
