Am J Psychiatry 1992; 149:1589-1591
Copyright © 1992 by American Psychiatric Association
Hyperventilation-induced cerebral ischemia in panic disorder and effect of nimodipine
DM Gibbs
Department of Neurology, Good Samaritan Hospital and Medical Center, Portland, Ore.
Basilar artery blood flow was measured by transcranial Doppler
ultrasonography before and during hyperventilation in nine patients with
panic disorder and nine normal comparison subjects. The
hyperventilation-induced decrease in basilar artery blood flow was
significantly greater in patients with panic attacks than in comparison
subjects. Two patients with decreases in basilar flow greater than 80% were
successfully treated with nimodipine, a centrally active calcium channel
blocker.