Prediction of outcome in mania by mood-congruent or mood-incongruent psychotic features



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Am J Psychiatry 1992; 149:1580-1584
Copyright © 1992 by American Psychiatric Association

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Prediction of outcome in mania by mood-congruent or mood-incongruent psychotic features

M Tohen, MT Tsuang and DC Goodwin
Department of Psychiatry, Harvard Medical School, Boston, MA.

OBJECTIVE: The aim of this study was to determine the significance of mood congruence of psychotic features in mania as a predictor of outcome. METHOD: Fifty-four patients with bipolar disorder were followed prospectively for 4 years after recovery from an episode of mania with psychotic features. Assessments of residential and occupational status, interepisode symptoms, and episode recurrences were made at 6 and 48 months after recovery. Categorical outcomes were evaluated by logistic regression and recurrence risk with survival analysis. RESULTS: Mood-incongruent psychotic features during the index manic episode predicted a shorter time in remission at 4 years (hazard ratio = 2.6), and Schneiderian first-rank symptoms predicted poor residential status at 4 years (odds ratio = 20.1). CONCLUSIONS: Differentiation of mood congruence of psychotic features in mania evidently has prognostic validity and, therefore, has utility as a nosological characteristic.

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