Am J Psychiatry 1992; 149:1395-1396
Copyright © 1992 by American Psychiatric Association
Comparison of fluorescent polarization immunoassay and radioimmunoassay in measuring cortisol levels in prepubertal depressed children
RA Weller, S Yaylayan, EB Weller and MA Fristad
Department of Psychiatry, Ohio State University College of Medicine, Columbus 43210.
Cortisol levels of 21 hospitalized prepubertal depressed children given the
dexamethasone suppression test (DST) were measured by radioimmunoassay and
by fluorescent polarization immunoassay, a new assay method. Correlation
analyses demonstrated a highly significant linear relationship between the
two methods of measuring cortisol. Thus, it may be possible to use
fluorescent polarization immunoassay to measure cortisol levels in children
undergoing the DST.
