|
| | |
|
Am J Psychiatry 1992; 149:22-32
Copyright © 1992 by American Psychiatric Association
Are schizophrenia and affective disorder related? A selective literature review
MA Taylor
Department of Psychiatry and Behavioral Sciences, University of Health Sciences, Chicago Medical School, IL 60064.
OBJECTIVE: Although most modern investigators accept the Kraepelinian view
that schizophrenia and affective disorder are biologically distinct, others
have suggested the psychoses are on a continuum of liability. This article
is a selective review of evidence for the continuum model. METHOD: The
author focuses on family, twin, and adoption data that do not support the
Kraepelinian view of psychosis. Evidence characterized to a lesser extent
includes the frequency of intermediate forms of illness (i.e.,
schizoaffective disorder), the inability to separate psychoses by classical
symptoms into well-defined clusters, and the inability of laboratory
measures to clearly define psychotic subgroups. RESULTS: The data
demonstrate that schizophrenia and affective disorder do co-occur in some
families. Whether this co- occurrence reflects true overlap is unclear, and
significant pathophysiological heterogeneity may underlie clinical
continuity. In some recent studies the inclusion of nonmelancholic
depressions in the affective illness category may have masked overlap.
CONCLUSIONS: The author suggests that the Kraepelinian view of psychoses
may need modification. Future research should focus on factors that may
reveal overlap between schizophrenia and affective disorder: severity of
schizophrenia and affective disorder in probands, severity of depression in
relatives, the effect of the unipolar-bipolar disorder relationship on the
co-occurrence of affective disorder and schizophrenia, and the relationship
of nongenetic factors that might alter the clinical expression of a shared
genotype. Also, investigators should not presume a dichotomy or continuum
but should examine pure and mixed pedigrees and look for state- and
trait-related endophenotypes, the convergence of which would provide the
basis for focused molecular genetic study.
This article has been cited by other articles:
|
|
|
|
 
C. R. Lake
Hypothesis: Grandiosity and Guilt Cause Paranoia; Paranoid Schizophrenia is a Psychotic Mood Disorder; a Review
Schizophr Bull,
December 1, 2007;
(2007)
sbm132v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. M. Williams, E. K. Green, S. Macgregor, S. Dwyer, N. Norton, H. Williams, R. Raybould, D. Grozeva, M. Hamshere, S. Zammit, et al.
Variation at the DAOA/G30 Locus Influences Susceptibility to Major Mood Episodes but Not Psychosis in Schizophrenia and Bipolar Disorder.
Arch Gen Psychiatry,
April 1, 2006;
63(4):
366 - 373.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Craddock, M. C O'Donovan, and M. J Owen
Genes for Schizophrenia and Bipolar Disorder? Implications for Psychiatric Nosology
Schizophr Bull,
January 1, 2006;
32(1):
9 - 16.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Olincy and L. Martin
Diminished Suppression of the P50 Auditory Evoked Potential in Bipolar Disorder Subjects With a History of Psychosis
Am J Psychiatry,
January 1, 2005;
162(1):
43 - 49.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L Sellen, M. Oaksford, and N. S Gray
Schizotypy and Conditional Reasoning
Schizophr Bull,
January 1, 2005;
31(1):
105 - 116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Hecker
Cyclothymia, a Circular Mood Disorder
History of Psychiatry,
September 1, 2003;
14(3):
377 - 390.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Malaspina, R. R. Goetz, J. H. Friedman, C. A. Kaufmann, S. V. Faraone, M. Tsuang, C. R. Cloninger, J. I. Nurnberger Jr., and M. C. Blehar
Traumatic Brain Injury and Schizophrenia in Members of Schizophrenia and Bipolar Disorder Pedigrees
Am J Psychiatry,
March 1, 2001;
158(3):
440 - 446.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. G. Siris
Depression in Schizophrenia: Perspective in the Era of "Atypical" Antipsychotic Agents
Am J Psychiatry,
September 1, 2000;
157(9):
1379 - 1389.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
V. A. Curtis, J. van Os, and R. M. Murray
The Kraepelinian Dichotomy: Evidence From Developmental and Neuroimaging Studies
J Neuropsychiatry Clin Neurosci,
August 1, 2000;
12(3):
398 - 405.
[Full Text]
|
|
|
|
|
|
|
K. L. Subotnik, K. H. Nuechterlein, R. F. Asarnow, D. L. Fogelson, M. J. Goldstein, and S. A. Talovic
Depressive Symptoms in the Early Course of Schizophrenia: Relationship to Familial Psychiatric Illness
Am J Psychiatry,
November 1, 1997;
154(11):
1551 - 1556.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J Flint, R Corley, J. DeFries, D. Fulker, J. Gray, S Miller, and A. Collins
A simple genetic basis for a complex psychological trait in laboratory mice
Science,
September 8, 1995;
269(5229):
1432 - 1435.
[Abstract]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1992
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
