Am J Psychiatry 1992; 149:118-120
Copyright © 1992 by American Psychiatric Association
Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients
SL Dubovsky, J Murphy, M Thomas and J Rademacher
Department of Psychiatry, University of Colorado, School of Medicine, Denver.
The authors measured intracellular Ca2+ concentrations in four manic and
five bipolar depressed patients and seven comparison subjects. Platelet and
lymphocyte intracellular Ca2+ concentrations were comparable. The patients'
mean intracellular Ca2+ concentrations were higher than those of the
comparison subjects and demonstrated more interindividual variation. These
findings suggest a diffuse abnormality in mechanisms affecting
intracellular calcium homeostasis in bipolar disorder.
