Effects of fluoxetine on regional cerebral blood flow in obsessive- compulsive patients



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Am J Psychiatry 1991; 148:1243-1245
Copyright © 1991 by American Psychiatric Association

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Effects of fluoxetine on regional cerebral blood flow in obsessive- compulsive patients

R Hoehn-Saric, GD Pearlson, GJ Harris, SR Machlin and EE Camargo
Department of Psychiatry, Johns Hopkins Hospital, Baltimore, MD 21205.

Six drug-free obsessive-compulsive patients were given single photon emission computerized tomography scans before and during treatment with fluoxetine. The treatment significantly reduced the patients' "hyperfrontality," as determined by the ratio between medial-frontal and whole cerebral cortex blood flow, and significantly lowered ratings of obsessive-compulsive and anxiety symptoms.

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