Elevation of plasma concentrations of haloperidol after the addition of fluoxetine



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Am J Psychiatry 1991; 148:790-792
Copyright © 1991 by American Psychiatric Association

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Elevation of plasma concentrations of haloperidol after the addition of fluoxetine

DC Goff, KK Midha, AW Brotman, M Waites and RJ Baldessarini
Erich Lindemann Mental Health Center, Boston, Mass.

Fluoxetine (20 mg/day) was added for 7-10 days to stable doses of haloperidol given to eight psychotic patients. Mean plasma concentrations of haloperidol were elevated by 20% (p less than 0.05), but extrapyramidal side effects did not increase appreciably, indicating a relatively minor interaction between these agents.

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