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Am J Psychiatry 1991; 148:1647-1658
Copyright © 1991 by American Psychiatric Association
A psychobiological perspective on the personality disorders
LJ Siever and KL Davis
Bronx VA Medical Center, Mt. Sinai School of Medicine, NY 10468.
A preliminary but growing body of evidence supports the existence of
genetic and biological substrates of personality, suggesting the utility of
a psychobiological perspective on the personality disorders. The
investigation of biological correlates of personality disorders can provide
an empirical base to explore the relationship between biological
predispositions and psychological function. The authors propose a
psychobiological model based on dimensions of cognitive/perceptual
organization, impulsivity/aggression, affective instability, and
anxiety/inhibition. These dimensions span the DSM-III- R axis I and axis II
disorders. The authors review phenomenological, genetic, and biological
evidence in relation to each of these dimensions. Although such an approach
remains heuristic, this model provides a promising vantage point from which
to generate investigation of the development and treatment of the
personality disorders.
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