Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients



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Am J Psychiatry 1991; 148:1586-1588
Copyright © 1991 by American Psychiatric Association

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Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients

B Adinoff, CB Nemeroff, G Bissette, PR Martin and M Linnoila
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md.

The authors performed the thyrotropin-releasing hormone (TRH) stimulation test and measured CSF concentrations of TRH in 13 abstinent alcohol-dependent subjects. They found an inverse correlation between the thyrotropin (TSH) response to TRH and endogenous CSF TRH concentrations. This finding supports the hypothesis that as the concentration of CSF TRH increases, anterior pituitary TRH receptor density decreases, resulting in a blunted TSH response to TRH stimulation.

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