Am J Psychiatry 1991; 148:127-129
Copyright © 1991 by American Psychiatric Association
Controlled comparison of buspirone and clomipramine in obsessive- compulsive disorder
MT Pato, TA Pigott, JL Hill, GN Grover, S Bernstein and DL Murphy
Laboratory of Clinical Science, NIMH, NIH, Bethesda, Md.
Eighteen outpatients with obsessive-compulsive disorder were treated with
either buspirone, a partial serotonin agonist, or clomipramine, a serotonin
uptake inhibitor, in a double-blind, random-assignment study. Both drugs
led to statistically significant and similar improvements in scores on the
Yale-Brown Obsessive-Compulsive Rating Scale and other obsessive-compulsive
and depression scales. This preliminary result warrants further exploration
with a larger sample and other serotonergic agents.
