|
| | |
|
Am J Psychiatry 1990; 147:1209-1215
Copyright © 1990 by American Psychiatric Association
A controlled trial of fluvoxamine in obsessive-compulsive disorder: implications for a serotonergic theory
MA Jenike, S Hyman, L Baer, A Holland, WE Minichiello, L Buttolph, P Summergrad, R Seymour and J Ricciardi
Harvard Medical School, Boston, MA.
Thirty-eight patients with primary obsessive-compulsive disorder
participated in a 10-week, double-blind, placebo-controlled trial of the
potent, selective serotonin reuptake inhibitor fluvoxamine. Fluvoxamine was
significantly better than placebo on two of three measures of improvement
in obsessive-compulsive symptoms. The authors also compared studies of the
serotonergic agents fluvoxamine, sertraline, fluoxetine, and clomipramine
and found that a greater effect size was associated with less serotonergic
specificity and that some ability to affect other neurotransmitter systems
may be a necessary but not sufficient requirement for antiobsessional
activity. These data lend only partial support to a serotonin hypothesis of
obsessive-compulsive disorder.
This article has been cited by other articles:
|
|
|
|
 
A. Kaplan and E. Hollander
A Review of Pharmacologic Treatments for Obsessive-Compulsive Disorder
Focus,
July 1, 2004;
2(3):
454 - 461.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Kobak, J. H. Greist, J. W. Jefferson, D. J. Katzelnick, and H. J. Henk
Behavioral Versus Pharmacological Treatments of Obsessive Compulsive Disorder: A Meta-Analysis
Focus,
July 1, 2004;
2(3):
462 - 474.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kaplan and E. Hollander
A Review of Pharmacologic Treatments for Obsessive-Compulsive Disorder
Psychiatr Serv,
August 1, 2003;
54(8):
1111 - 1118.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. Dougherty, L. Baer, G. R. Cosgrove, E. H. Cassem, B. H. Price, A. A. Nierenberg, M. A. Jenike, and S. L. Rauch
Prospective Long-Term Follow-Up of 44 Patients Who Received Cingulotomy for Treatment-Refractory Obsessive-Compulsive Disorder
Am J Psychiatry,
February 1, 2002;
159(2):
269 - 275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. Wylie, M. D. Miller, M. K. Shear, J. T. Little, B. H. Mulsant, B. G. Pollock, and C. F. Reynolds
Fluvoxamine Pharmacotherapy of Anxiety Disorders in Later Life: Preliminary Open-Trial Data
J Geriatr Psychiatry Neurol,
April 1, 2000;
13(1):
43 - 48.
[Abstract]
[PDF]
|
|
|
|
|
|
|
V. Gentil, F. Lotufo-Neto, L. Andrade, T. Cordas, M. Bernik, R. Ramos, L. Maciel, E. Miyakawa, and C. Gorenstein
Clomipramine, a better reference drug for panic/agoraphobia. I. Effectiveness comparison with imipramine
J Psychopharmacol,
January 1, 1993;
7(4):
316 - 324.
[Abstract]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1990
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
