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Am J Psychiatry 1990; 147:1138-1148
Copyright © 1990 by American Psychiatric Association
Continuous versus targeted medication in schizophrenic outpatients: outcome results [published erratum appears in Am J Psychiatry 1991 Jun;148(6):819]
WT Carpenter Jr, TE Hanlon, DW Heinrichs, AT Summerfelt, B Kirkpatrick, J Levine and RW Buchanan
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228.
The authors report on the outcome of treatment of 116 outpatients with
chronic schizophrenia who were assigned to a 2-year, single-blind course of
treatment with either targeted or continuous medication. These patients
were not restricted to those who were good candidates for a medication
reduction strategy. Continuous medication was superior to targeted
medication in preventing decompensations and hospitalizations and in extent
of employment at 2 years. Other measures of psychopathology and functioning
at 1 and 2 years did not differentiate the two groups of patients. The
targeted approach achieved a substantial reduction in total medication
through a reduction in the number of days of medication administration.
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