Am J Psychiatry 1990; 147:777-779
Copyright © 1990 by American Psychiatric Association

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Serum prolactin levels during extended cocaine abstinence

CM Swartz, K Breen and F Leone
Department of Psychiatry, University of Health Sciences/Chicago Medical School, IL 60064.

Following a report indicating almost a 100% risk for hyperprolactinemia in cocaine users after 1 month of abstinence, the authors determined the serum prolactin concentrations of 23 male inpatients who had abstained from cocaine for 2-43 weeks. None showed high prolactin levels; this places the incidence below 12.3% with 95% confidence. These results imply that persistent hyperprolactinemia requires a medical explanation other than cocaine abstinence itself.

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